Microcrystalline Cellulose Uses in Pharmaceuticals

USP ingredient supplier Bell Chem’s microcrystalline cellulose is a white excipient renowned for its multiple functionality. The name “microcrystalline” determines the granule size and shape, and microcrystalline cellulose is a USP-grade form of cellulose. While many inactive ingredients utilized by the pharmaceutical industry work as binders, bulking agents, and lubricants, microcrystalline cellulose (MCC) adds several additional layers of usefulness to its resume. Read more to learn how advantageous MCC is for your industry.

Bioadhesive advantages

The term “microcrystalline” refers to the size and shape of MCC. Its tiny particle size offers an extreme surface area for adhesion within the human body. MCC delivers medication as it binds to these tissues.

Compression/compaction

With the ability to carry active ingredients, along with its high dilution capacity (its ability to compact under specific conditions) – both of which exceed leading excipients – MCC is a proven leader. MCC’s ability to compress medication into smaller tablets leads to less crumbling. 

Disintegrant

In both wet and dry compressions, MCC expedites the breakdown of medication into microscopic form for the body’s use. Compared to similar excipients, MCC causes faster disintegration, leading to a quick-acting medication for consumers. This feature leads to MCC’s addition as an ingredient to chewable and dissolvable medications.

Filler/bulking agent/binder

As an excipient, MCC is foremost a filler. By adding MCC as an inactive ingredient, manufacturers are able to deliver a familiar low-dose medication in liquid, capsule, or tablet form with precise measurements of medicine bound tightly and compactly by MCC. Its bulking property gives a weak liquid, which is easier to spill and more difficult for some patients to consume, a boost in viscosity by transforming it into a semi-solid syrup. 

Lubricant

The flow rate of MCC gives it a space as a lubricant in pharmaceutical manufacturing. Added to active ingredients, it causes a smooth flow with less risk of adhering to machinery. 

Wet granulation

Because MCC is hydrophilic and insoluble in water, it is one of the few excipients available for wet granulation processes. As it retains water, the interior of the granules remain moist as the exterior dries when exposed to a high temperature.

Bell Chem is a USP ingredient supplier based in Longwood, FL (just north of Orlando) with hundreds of products stocked in their 50,000+ square-foot warehouse, including versatile microcrystalline cellulose. You can expect the highest quality products, expedited shipping options for maximum efficiency, and unrivaled personalized customer service. Let our knowledgeable and friendly customer service representatives and accounting staff personalize all your needs by either calling 407-339-BELL (2355) or by sending us an online message.